What is the expiration date for solid or nonaqueous compounds?

The correct answer outlines that the expiration date for solid or nonaqueous compounds should not exceed 25% of the time remaining on the commercial product's expiration date. This guideline is particularly crucial when repackaging, as it ensures that the compounded product remains safe and effective for a reasonable timeframe based on the stability of the original commercial drug product.

In pharmacy practice, determining an appropriate expiration date for compounded medications is essential for patient safety and pharmaceutical efficacy. When a pharmacist receives a commercial product, they often have a specific expiration date based on stability testing performed by the manufacturer. If a compounded solid or nonaqueous compound is made from that product, using the 25% rule allows for a conservative extension of the expiration date, ensuring that the compounded form is not held for too long and exposing patients to potentially ineffective or unsafe compounds.

Other possibilities such as setting an expiration date for no more than 6 months from repackaging or one year from the date made lack the contextual justification provided by relating it directly to the stability of the original product. Similarly, basing it solely on stability testing without considering the remaining shelf life of the original product also does not align with the best practices in compounding, where both the original manufacturer's data and the nature of