Which of the following drugs is associated with REMS?

The Correct choice is associated with the Risk Evaluation and Mitigation Strategy (REMS) program because it is a requirement for certain medications that have significant risks of serious adverse effects. Alendronate, which is used primarily for the treatment of osteoporosis, can have serious side effects, including potential risks for osteonecrosis of the jaw and atypical femoral fractures. Because of these risks, a REMS program is necessary to ensure that healthcare providers, pharmacists, and patients are adequately informed about these dangers and are taking appropriate precautions.

The other drugs listed, such as ibuprofen, aspirin, and acetaminophen, do not require a REMS program as they are generally considered to have a much lower risk profile for serious adverse effects, especially when used as directed. These medications are over-the-counter and have well-established safety profiles that do not necessitate the same level of risk management and monitoring that REMS aims to provide for more high-risk medications like alendronate.