Which schedule of drugs has the highest potential for abuse?

The correct answer is Schedule I, which is classified as having the highest potential for abuse among drug schedules. Schedule I drugs are substances that are considered to have no accepted medical use in the United States and a high potential for abuse. This classification means that these drugs are strictly controlled and are illegal to manufacture, distribute, or possess, except for research purposes that are heavily regulated.

The determination of a drug being placed in Schedule I is based on its potential to lead to severe psychological or physical dependence. Examples of Schedule I substances include heroin, cocaine, and hallucinogenic drugs like LSD.

In contrast, Schedule II drugs, while still possessing a high potential for abuse, may have accepted medical uses and can be prescribed under strict regulations. Schedule III and Schedule IV drugs have progressively lower potentials for abuse. Having this categorization helps ensure that substances are managed safely and responsibly within medical, legal, and regulatory frameworks.